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Department of Pathology, Primary Children's Medical Center and University of Utah School of Medicine, Salt Lake City, Utah daggerDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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Less often, this drug can also cause problems with fluid retention, liver damage, and severe allergic reaction.

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From this base, we expect Pharma sales to be, in 2016, in line with 2015 or slightly below, Alcon to deliver low single-digit growth for the full year, and Sandoz to deliver low to mid single-digit growth.

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Humanization is not an issue for small-molecule compounds because they are not typically recognized by the body as foreign.

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Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update.

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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.

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There is a need for further studies to evaluate cardiotoxicity in patients receiving the substance, taking into account dose levels of the drug, pre-existing cardiac conditions, and the use of additional cardiotoxic drugs ().

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CEL patients experienced at least one adverse event, the most common being gastrointestinal, cutaneous and musculoskeletal disorders.

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Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.

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As the drug-pricing debate intensified over the last 8 months, we've heard a common refrain from pharma: List prices are misleading.

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In principle, failure to control CML by treatment with imatinib can be caused by three entirely different biological mechanisms ().

The latest findings build on earlier work by Sawyers group that showed that mutations in BCR-ABL underlie resistance to Gleevec, a drug that has shown remarkable potency against CML.

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Bleeding also can cause a person to vomit blood.

I've been on gleevec since Jan 2006.

Gleevec is dosed once daily.

Robinson said he hopes that in the near future, clinical trials will be conducted that look at the drug's effectiveness for a range of autoimmune diseases.

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Notify your healthcare provider if you notice yellowing of the skin or eyes, your urine appears dark or brown or pain in your abdomen, as these can be signs of liver toxicity.

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National Institutes of Health (NIH).

Sawyers et al found that among patients in myeloid blast crisis (260 patients) treatment with imatinib resulted in sustained hematologic responses lasting at least 4 weeks in 31% of patients, including complete hematologic responses in 8%.

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Immunotherapy of chronic myeloid leukemia: present state and future prospects.

So putting them into Sandoz will allow us to create more value than just watching them decline as mature products.

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Her recommendation was to 'continue what you are doing, because it's working'.

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And we missed it I think on the first round, but with PanOptix and with toric we are able to command premium prices.

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Close monitoring of growth in children under Imatinib Mesylate treatment is recommended.

NEWS REPORTER 2: Cancer specialists are hailing the development of a new drug with remarkable results.

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Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ketoconazole and each time you refill your prescription.

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Imatinib blocks the activity of an enzyme known as tyrosine kinase, which delivers a signal that causes cells to multiply.

How do researchers find biological pathways?

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